
姓名:彭辰
性别:男
职称:教授
职务:预防兽医学系副系主任
学位:博士
所在系:预防兽医系
导师类型:博导兼硕导
出生年月:1988年2月
电子邮件:pengchenea@cau.edu.cn
办公电话:010-62734161
个人简介
彭辰,欧宝综合教授,博士生导师,主要研究痘病毒宿主嗜性性的分子机制及痘病毒载体疫苗开发。博士毕业于堪萨斯州立大学生物学系,博士后供职于美国洛克斐勒大学(The Rockefeller University)以及美国国立卫生研究院(National Institutes of Health, NIH)过敏症与传染病研究所(NIAID),师从美国科ob欧宝电竞官网入口Bernard Moss院士,主要致力于研究痘病毒拮抗天然免疫反应的分子机制。2021年加入欧宝综合全职工作。
学术兼职:
1. 中国微生物学会兽医微生物专业委员会委员;
2. 国家动物健康与食品安全创新联盟副秘书长;
3. 美国病毒学会(American Society of Virology)会员;
4. 《Frontiers in Cellular and Infection Microbiology》、《中国兽医杂志》编委,《OneHealth Advances》科学编辑。
工作经历
2016.6-2017.6 美国堪萨斯州立大学,博士后
2017.7-2018.1 美国洛克菲勒大学,博士后
2018.1-2020.12 美国国立卫生研究院(NIH)免疫与传染病研究所(NIAID),博士后
2021.02-今 欧宝综合 教授
研究领域
主要研究方向包括牛痘、牛结节性皮肤病、羊痘、猴痘等人兽共患痘病毒的复制机制以及免疫拮抗的分子机制;通过研发痘病毒抗病毒药物、疫苗、诊断试剂等,为牛痘、牛结节性皮肤病、猴痘等疫病的防控提供理论和技术支持;以改良牛痘病毒为载体研发针对各类传染病,如牛病毒性腹泻,新型冠状病毒肺炎等疫病的载体疫苗;开发靶向人或宠物癌症的新型溶瘤病毒治疗药物。
获奖及荣誉
获北京市科技新星 (2022)
第十二届大北农科技奖一等奖 排名第5 (2022)
北京市科技进步二等奖 排名第3 (2022)
教学工作
病毒学与细菌学研究技术(硕士,主讲)
兽医专业英语(博士,主讲)
兽医大意(本科,主讲)
动物疫病学(本科,参讲)
动物检疫学实验(本科,主讲)
在研项目
1. 牛结节性皮肤病病毒复制机制的研究与抗病毒药物设计
国家“十四五”重点研发计划青年科学家项目,主持
2. PLK1调控牛结节性皮肤病病毒复制的分子机制
国家自然科学基金面上项目,主持
3. 泰勒菌素抑制牛结节性皮肤病病毒复制的分子机制
国家自然科学基金面上项目,主持
4. 牛结节性皮肤病病毒致病性与宿主嗜性机制的研究
国家级青年人才项目,主持
5. 北京市科技新星计划
MVA靶向溶瘤病毒的研究,主持
代表性文章
* 通讯作者:
1. Sun, X., Zhang, L., Chen, G., Yang, F., Ning, X., Qiu, J., Gao, Y., Yang, J., Zhang, W., Zhang, Z., Zhang, Y., Li, S., Zeng, M., Fu, B.*, Li, Y.*, Peng, C.*, Li, W.* A cocktail vaccine with monkeypox virus antigen confers protection without selecting mutations in potential immune evasion genes in the vaccinia WR strain challenge. mBio. 2025
2. Zhu, J., Zhang, Z., Fang, Y., Xu, J., Jiang, Z., Li, H., Xie, S., Niu, K., Jing, Z., Song, B., Wu, W., Peng, C.* Poxvirus H5 mediates the formation of liquid-liquid phase separation condensates which promote virus factory assembly. PLoS Pathogens. 2025
3. Niu, K., Wang, X., Jiang, Q., Liu, K., Xie, S., Song, B., Wu, W., Li, X.*, Peng, C.* Ibrutinib inhibits the replication of multiple poxviruses by targeting the Bruton tyrosine kinase. Journal of Virology. 2025.
4. Xie, S., Fang, Y., Liao, Z., Cui, L., Niu, K., Ren, S., Zhu, J., Wu, W., Jing, Z., Peng, C.*.
A poxvirus protein ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability. PLoS Pathogens. 2025.
5. Li, H., Zhu, J., Qin, W., Wang, Z., Xie, S., Zhang, Z., Wang, J., Song, B., Wu, W., Peng, C.* Modified vaccinia virus Ankara selectively targets human cancer cells with low expression of the Zinc-finger antiviral protein. Journal of Medical Virology. 2025.
6. Zhu, J., Jia, X., Ren, S., Zhang, Z., Li, H., Wang, J., Song, B., Wu, W., Peng, C.* Inhibition of Polo-like kinase 1 dampens the replication of vaccinia virus in mammalian cells. Journal of Medical Virology. 2025
7. Zhu, J., Wang, Z., Li, Y., Zhang, Z., Ren, S., Wang, J., Xie, S., Liao, Z., Song, B., Wu, W., Yan, F.*, Peng, C.* Trimerized S expressed by modified vaccinia virus Ankara (MVA) confers superior protection against lethal SARS-CoV-2 challenge in mice. Journal of Virology. 2024
8. Xie, S., Cui, L., Liao, Z., Zhu, J., Ren, S., Niu, K., Li, H., Jiang, F., Wu, J., Wang, J., Wu, J., Song, B., Wu, W.*, Peng, C.* Genomic analysis of lumpy skin disease virus Asian variants and evaluation of its cellular tropism. NPJ Vaccines. 2024
9. Xu, J., Liu, L., Zhi, F., Song, Y., Zhang, Z., Li, B., Zheng, F., Gao, P., Zhang, S., Zhang, Y., Zhang, Y., Qiu, Y., Jiang, B., Li, Y., Peng, C.*, Chu, Y.* DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection. EMBO Reports. 2024
10. Zhu, J., Gao, X., Li, Y., Zhang, Z., Xie, S., Ren, S., Li, Y., Li, H., Niu, K., Fu, S., Deng, Y., Li, Y., Moss, B., Wu, W.*, Peng, C.* Human Fam111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1. Proceedings of the National Academy of Sciences of USA, 2023
11. Wang, J., Zhu, J., Ren, S., Zhang, Z., Niu, K., Li, H., Wu, W.*, Peng, C.* The role of ferroptosis in virus infections. Frontiers in Microbiology. 2023
12. Zhao, H., Zhang, Y., Wang, Z., Liu, M., Wang, P., Wu, W.*, Peng, C.* MBOVPG45_0375 encodes an IgG-binding protein and MBOVPG45_0376 encodes an IgG-cleaving protein in mycoplasma bovis. Frontiers in Veterinary Science. 2021
13. Wang, P., Huang, S., Hao, C., Wang, Z., Zhao, H., Liu, M., Tian, X., Ge, L., Wu., W.*, Peng, C.* Establishment of a suspension MDBK cell line in serum-free medium for production of bovine alphaherpesvirus-1. Vaccines. 2021
14. Wang, ZH., Liu, MY., Zhao, HR., Wang, PP., Ma, WG., Zhang, YK., Wu, WX*, Peng, C.* Induction of Robust and Specific Humoral and Cellular Immune Responses by Bovine Viral Diarrhea Virus Virus-like Particles Engineered with Baculovirus Expression System. Vaccines. 2021
15. Peng, C., Wyatt, LS., Glushakow-Smith SG., Lal-Nag, M., Weisberg, AS., Moss, B.* Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells. PLoS Pathogens. 2020
16. Peng, C., and Moss B.* Repair of a newly identified host range gene contributes to full replication of modified vaccinia virus Ankara (MVA) in human cells. Proceedings of the National Academy of Sciences of USA. 2019
17. Peng, C., Haller, S., Rahman, M., McFadden, G. and Rothenburg, S.* Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates. Proceedings of the National Academy of Sciences of USA. 2016



