欧宝综合

2009年8月-2016年12月，Purdue University，农业ob欧宝电竞官网入口，生物化学系，获得博士学位，导师：Scott Briggs教授

2005年8月-2009年6月，北京大学，生命科学ob欧宝电竞官网入口，获得理学学士学位，导师：郑晓峰教授

2019年7月至今，欧宝综合app，欧宝综合体育，副教授

2017年7月-2019年6月，北京化工大学，高精尖中心，博士后，合作导师：中国工程院外籍院士Jens Nielsen教授

合成生物学，创新型疫苗（病毒样颗粒疫苗、mRNA疫苗等），犬猫病毒疾病的诊断与预防

本科生课程：生物统计学（动医类）（秋季，主讲），动物生物化学实验（秋季，参讲）

研究生课程：兽医生物医学文献阅（春季，主讲）

主持国家自然科学基金委青年科学基金项目一项，曾获第12批中国博士后科学基金特别资助，参与重点研发计划（合成生物学）“酿酒酵母基因组深度设计原则研究”项目,参与十四五国家重点研发计划“野生动物重要疫病防控关键技术研发”项目。

学术论文：发表SCI科研论文20多篇，包括Nature Communications （2篇）等高水平杂志，其中Nature Communications单篇引用294次（被评为高被引用论文）。

[1] Xiaolong Teng#, Zibai Wang#, Yueping Zhang#, Binhao Wang, Guiping Gong, Jinmiao Hu, Yifan Zhu, Baoyi Peng, Junyang Wang, James Chen, Shuobo Shi, Jens Nielsen & Zihe Liu*. Matrix regulation: a plug-and-tune method for combinatorial regulation in Saccharomyces cerevisiae. Nature Communications. 2025, 16, 7624. doi: 10.1038/s41467-025-62886-5

[2] Xiaohu Zhang#, Jingru Zhu#, Di Zhang*, Yueping Zhang*, Development of a yeast-based CRISPR genome editing system for feline coronavirus. Frontiers in Microbiology, 2025 Aug 14, DOI: 10.3389/fmicb.2025.1627509

[3] Wei Yuan#, Xiaoen Pang#, Jingru Zhu#, Zan Chen#, Shuna Li, Zhibo Yang, Xiaohu Zhang, Changbin Jin, Xintong Huang, Yu Shen, Huarong Fang, Jiahao Lin*, Yueping Zhang*, Identification and Evaluation of Nordihydroguaiaretic Acid (NDGA) as an Active Traditional Chinese Medicine Compound Inhibiting the 3C-Like Protease of Feline Infectious Peritonitis Virus, Veterinary Microbiology, 2025, 110730, ISSN 0378-1135, doi: 10.1016/j.vetmic.2025.110730.

[4] Xintong Huang#, Muwu Chen#, Zan Chen, Yueping Zhang*, Fungal β-1,3-Glucan Synthase: A Review of Structure, Mechanism, and Regulation, FEMS Yeast Research. 2025, foaf071, doi: 10.1093/femsyr/foaf071

[5] Junyi Li#, Qi Yang#, Zhibo Yang#, Yangnan Huyan, Yi Xiong, Miao Sun, Yueping Zhang*, Xinzheng Zhang*, Geng Meng*, Structural and immunogenic characteristics of goose parvovirus virus-like particles. Virology. 2026 Feb:614:110727, doi: 10.1016/j.virol.2025.110727. Epub 2025 Nov 19.

[6] Junyi Li#, Qi Yang#, Zhibo Yang#, Yangnan Huyan, Yi Xiong, Miao Sun, Yueping Zhang*,

Xinzheng Zhang*, Geng Meng*. Structural insights into mink enteritis virus host specificity: capsid architecture, receptor recognition, and evolutionary dynamics. One Health Advances. 2025. 3, 31, doi: 10.1186/s44280-025-00097-9.

[7] Pingping Gao, Shuobo Shi, Di Zhang*, Yueping Zhang*, Rapid and visual RPA-CRISPR/Cas12a detection for Staphylococcus pseudintermedius and methicillin-resistant S. pseudintermedius in clinical samples of dogs and cats. One Health Advances. 2023, 1:20. doi: 10.1186/s44280-023-00021-z

[8] Junhao Cheng, Baseer Ahmad, Muhammad Asif Raza, Henan Guo, Marhaba Ahmat, Xubiao Wei, Lulu Zhang, Zhongxuan Li, Qiang Cheng, Jing Zhang, Junyong Wang, Dayong Si, Yueping Zhang*, Rijun Zhang*. Yeast Expressed Hybrid Peptide CLP Abridged Pro-Inflammatory Cytokine Levels by Endotoxin Neutralization. Microorganisms. 2023 Jan 4;11(1):131. doi: 10.3390/microorganisms11010131.

[9] Zehui Qu#, Hongtao Kang#, Chenxi Cui, Kaiwen Meng, Xinzheng Zhang, Liandong Qu, Yueping Zhang*, Geng Meng*, Purification-induced damage to calicivirus particles at near-atomic resolution. Journal of General Virology. 2022 103(5), DOI: 10.1099/jgv.0.001742

[10] Kaiwen Meng#, Yueping Zhang#, Qi Liu, Yangnan Huyan, Wenzhuang Zhu, Ye Xiang and Geng Meng*, Structural Design and Assessing of Recombinantly Expressed African Swine Fever Virus p72 Trimer in Saccharomyces cerevisiae, Frontiers in Microbiology, 2022, 13:802098, DOI: 10.3389/fmicb.2022.802098

[11] Yijin Zhao, Kaiwen Meng, Jinyu Fu, Shijie Xu, Guang Cai, Geng Meng, Jens Nielsen, Zihe Liu* & Yueping Zhang*, Protein engineering of invertase for enhancing yeast dough fermentation under high sucrose conditions. Folia Microbiol (Praha). 2023 Apr;68(2):207-217. doi: 10.1007/s12223-022-01006-y. Epub 2022 Oct 6.

[12] Zhibo Yang#, Zan Chen#, and Yueping Zhang*, A simple and economical site-directed mutagenesis method for large plasmids by direct transformation of two overlap PCR. Biotechniques. 2022 Nov 18, DOI: 10.2144/btn-2022-0085

[13] Liyang Wang#, Jinyu Fu#, Guang Cai, Xiyu Cheng, Di Zhang, Shuobo Shi*, and Yueping Zhang*, Rapid and Visual RPA-Cas12a Fluorescence Assay for Accurate Detection of Dermatophytes in Cats and Dogs. Biosensors 2022, 12(8), 636; DOI: 10.3390/bios12080636

[14] Junhao Cheng, Marhaba Ahmat, Henan Guo, Xubiao Wei, Lulu Zhang, Qiang Cheng, Jing Zhang, Junyong Wang, Dayong Si, Yueping Zhang*, Rijun Zhang*, Expression, Purification and Characterization of a Novel Hybrid Peptide CLP with Excellent Antibacterial Activity. Molecules 2021, 26, 7142. DOI: 10.3390/molecules26237142

[15] Junhao Cheng, Mingkun Wu, Ren Zhong, Dayong Si, Geng Meng, Rijun Zhang*, Yueping Zhang*, Rapid Golden Gate assembly of exons from genomic DNA for protein expression in Escherichia coli and Pichia pastoris. Biotechniques. 2021 Aug 10. DOI: 10.2144/btn-2021-0039

[16] Yu Fu, Zhenglin Zhu, Geng Meng, Rijun Zhang*, Yueping Zhang*, A CRISPR-Cas9 based shuffle system for endogenous histone H3 and H4 combinatorial mutagenesis. Scientific Reports. 2021, Feb 8;11(1):3298, DOI: 10.1038/s41598-021-82774-4

[17] Jinyu Fu#, Yueping Zhang#, Guang Cai, Geng Meng*, Shuobo Shi*, Rapid and sensitive RPA-Cas12a-fluorescence assay for point-of-care detection of African swine fever virus. PLoS One. 2021 Jul 19;16(7):e0254815. DOI: 10.1371/journal.pone.0254815

[18] Guiping Gong#, Yueping Zhang#, Zibai Wang, Luo Liu, Shuobo Shi, Verena Siewers, Qipeng Yuan, Jens Nielsen, Xu Zhang*, and Zihe Liu*, GTR 2.0: gRNA-tRNA Array and Cas9-NG Based Genome Disruption and Single-Nucleotide Conversion in Saccharomyces cerevisiae. ACS Synthetic Biology. 2021 Jun 18;10(6):1328-1337., DOI: 10.1021/acssynbio.0c00560

[19] Yijin Zhao#, Yueping Zhang#, Jens Nielsen, Zihe Liu*, Production of β‐carotene in Saccharomyces cerevisiae through altering yeast lipid metabolism. Biotechnology and Bioengineering. 2021 May;118(5):2043-2052. DOI: 10.1002/bit.27717

[20] Yueping Zhang#, Juan Wang#, Zibai Wang, Yiming Zhang, Shuobo Shi, Jens Nielsen, Zihe Liu*, A gRNA-tRNA Array CRISPR-Cas9 Based Rapid Multiplexed Genome Editing in Saccharomyces cerevisiae. Nature Communications. 2019 Mar 5;10(1):1053, DOI: 10.1038/s41467-019-09005-3

[21] Yueping Zhang, Jens Nielsen, Zihe Liu*, Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels. FEMS Yeast Research. 2017 Dec 1;17(8), DOI: 10.1093/femsyr/fox080

[22] Yueping Zhang, Nina D. Serratore, Scott D. Briggs*, (2017) N-ICE plasmids for generating N-terminal 3×FLAG tagged genes that allow Inducible, Constitutive, or Endogenous expression in Saccharomyces cerevisiae. Yeast. 2017 May;34(5):223-235, DOI: 10.1002/yea.3226

中文论文：

[1] 郜平平，付金玉，王丽仰，史硕博*，张跃平*，张迪*，基于RPA-CRISPR/Cas12a技术快速检测犬猫皮肤癣菌方法的建立，畜牧兽医学报 . 2023 ,54 (11)

[2]郑好，黄欣桐，杨智博，金艺鹏，张跃平*，猫泛白细胞减少症主要病原研究进展，中国兽医杂志. 2023 ,59 (04)

发表专利：

[1] 一种猫冠状病毒及其应用和猫传染性腹膜炎动物模型的构建方法，申请(专利)号：

CN202510375637.7，申请公布日：2025-08-12

[2] 一种基于Cas13鉴别检测犬猫细小病毒的crRNA及其应用，申请(专利)号：CN202510628031.X，申请公布日： 2025-09-19

[3] 去甲二氢愈创木酸在制备抑制猫传染性腹膜炎病毒的药物中的应用，授权公告号：CN 118001261B，授权公告日： 2024年08月23日。

[4] 一种非洲猪瘟病毒衣壳蛋白P72及其制备方法和应用，授权公告号：CN 118001261B，授权公告日：2021年8月3日。

[5] 一种非洲猪瘟免疫抗原及其制备方法和应用，授权公告号：CN202010240109.8，授权公告日：2020年3月30日。

[6] 产β-胡萝卜素的基因工程菌及其应用，授权公告号：CN201911393283.X， 授权公告日：2020年5月1日