欧宝综合

2008.09 — 2011.07  欧宝综合app，预防兽医学，博士

2001.09 — 2008.07  山东农业大学，动物医学（学士）、预防兽医学（硕士）

2019.05 — 至  今  欧宝综合，副教授

2016.08 — 2017.08  美国堪萨斯州立大学兽医ob欧宝电竞官网入口，访问学者

2011.07 — 2019.04  中国检验检疫科学研究院，助理研究员、副研究员

猪病诊断与诊断试剂研发，ASFV、PDCoV等重要猪病毒病致病机制与免疫逃逸机制研究

2022年  北京市普通高等学校优秀本科生毕业设计（论文）优秀指导教师

2018年  北京市科学技术奖

2013年  国家质量监督检验检疫总局“科技兴检奖”

[1] 主讲本科生课程《动物检疫学及实验》

[2] 主讲本科生课程《兽医免疫学及实验》

[3] 参讲硕士研究生课程《兽医免疫学进展》

[4] 参讲博士研究生课程《预防兽医学专业Seminar》

[5] 参讲本科生课程《兽医公共卫生概论》

[1] 国家重点研发计划子课题“ASFV不同毒株诱导宿主细胞凋亡与炎症损伤差异机制研究” （100万元）

[2] 国家重点研发计划子课题“ASFV调控细胞死亡的分子机制”（180万元）

[1] Meirong Chen, Xin Zhang, Fanshu Kong, Peng Gao, Xinna Ge, Lei Zhou, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang*. Senecavirus A induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185. Autophagy, 2024, 20(6): 1286?1313.

[2] Yongning Zhang#, Zhongchang Li, Xinna Ge, Xin Guo, Hanchun Yang. Autophagy promotes the replication of encephalomyocarditis virus in host cells. Autophagy, 2011, 7(6): 613?628.

[3] Jianyu Zeng, Xin Zhang, Jingting Zhao, Qiang Li, Zhiyong Xiang, Fengyang Shi, Hua Wang, Wenlian Weng, Qiongqiong Zhou, Peng Gao, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang. The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway. Journal of Virology, 2026, doi: 10.1128/jvi.01952-25.

[4] Zhiyong Xiang, Zhen Xu, Wenlian Weng, Hua Wang, Jiajun Wu, Fei Jiang, Yajin Qu, Quanlin Li, Peng Gao, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Yongning Zhang*, Hanchun Yang*. Journal of Virology, 2025, 99(4): e0140124.

[5] Zhiyong Xiang, Huan Ye, Peng Gao, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Yongning Zhang*, Hanchun Yang*. Preparation and characterization of monoclonal antibodies against the pp62 protein of African swine fever virus. Journal of Integrative Agriculture, 2025, 24(6): 2443?2447.

[6] Jianyu Zeng, Wenlong Wang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yanhong Chen, Yongning Zhang*, Hanchun Yang*. A nucleic acid detection assay combining reverse transcription recombinase-aided amplification with a lateral flow dipstick for the rapid visual detection of porcine deltacoronavirus. Virulence, 2022, 13(1): 1471?1485.

[7] Xin Zhang, Lei Zhou, Xinna Ge, Peng Gao, Qiongqiong Zhou, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang. Advances in the diagnostic techniques of African swine fever. Virology, 2025, 603: 110351.

[8] Minhui Yang, Xinna Ge, Lei Zhou, Xin Guo, Jun Han, Yongning Zhang*, Hanchun Yang. Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein. Applied Microbiology and Biotechnology, 2024, 108(1): 173.

[9] Xi Li, Huan Ye, Xinna Ge, Lei Zhou, Xin Guo, Jun Han, Yongning Zhang*, Hanchun Yang*. Identification of two immunodominant and neutralizing linear B-cell epitopes exposed on the surface of the porcine deltacoronavirus spike protein. Veterinary Research, 2026, doi: 10.1186/s13567-025-01690-x

[10] Huan Ye, Qiang Li, Shuci Liu, Lei Zhou, Xinna Ge, Peng Gao, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang. Identification of two conserved linear antigenic epitopes on the 2C protein of Senecavirus A. Virology, 2025, 607: 110525.

[11] Ming Liu, Huifen Huang, Peng Gao, Qiongqiong Zhou, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang. A quantum dot-based double-antibody sandwich immunochromatographic strip for rapid detection of porcine deltacoronavirus targeting the nucleocapsid protein. Microbial Pathogenesis, 2026, 210: 108152.

[12] Xinrong Zhou, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Yongning Zhang*, Hanchun Yang*. Quantitative proteomic analysis of porcine intestinal epithelial cells infected with porcine deltacoronavirus using iTRAQ-coupled LC-MS/MS. Journal of Proteome Research, 2020, 19(11): 4470?4485.

[13] Xinrong Zhou, Lei Zhou, Pingping Zhang, Xinna Ge, Xin Guo, Jun Han, Yongning Zhang*, Hanchun Yang*. A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full-length cDNA infectious clone. Transboundary and Emerging Diseases, 2021, 68(4): 2130?2146.

[14] Wenlong Wang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yanhong Chen, Yongning Zhang*, Hanchun Yang*. Development of a VP2-based real-time fluorescent reverse transcription recombinase-aided amplification assay to rapidly detect Senecavirus A. Transboundary and Emerging Diseases, 2022, 69(5): 2828?2839.

[15] Huan Ye, Xiaonan Wang, Lei Zhou, Xinna Ge, Peng Gao, Jun Han, Xin Guo, Kai Wen, Yongning Zhang*, Hanchun Yang. Development of a triplex RT-RAA-LFA assay for the rapid differential diagnosis of porcine epidemic diarrhea virus, porcine deltacoronavirus and transmissible gastroenteritis virus. Microbial Pathogenesis, 2024, 195: 106885.

[16] Wenlong Wang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yongning Zhang*, Hanchun Yang. Analysis of codon usage patterns of porcine enteric alphacoronavirus and its host adaptability. Virology, 2023, 587: 109879.