欧宝综合

09/2005-07/2010，北京大学生命科学ob欧宝电竞官网入口，生物化学和分子生物学，理学博士学位，导师：郑晓峰，罗明

09/2000-07/2005，欧宝综合，农学学士学位

07/2017 至今，欧宝综合，副教授

01/2016-07/2017，BBI Solution，Scientific consultant

01/2011-01/2016， Purdue University（普度大学）生物ob欧宝电竞官网入口，结构病毒学，博士后研究员，导师：Michael G Rossmann

基础科研：结构病毒学（X射线衍射晶体学和高分辨率冷冻电镜），病毒组装机制研究。

应用科研： 诊断试剂及疫苗研发。

1、2025年北京市大学生生物竞赛二等奖 指导老师

2、2025年中国国际大学生创新大赛北京市二等奖 指导老师

3、2025年“强农杯”欧宝综合app第六届创新创业大赛三等奖 指导老师

本科生课程：《兽医结构病毒学》

研究生课程：《兽医结构病毒学前沿》，《冷冻电镜三维重构技术及应用》

1、RNA病毒及单链DNA病毒组装，基因组释放及相关表型机制研究

2、畜禽病毒病病毒样颗粒疫苗研发

3、畜禽疫病诊断试剂研发

2026

1: Li J, Yang Q, Yang Z, Huyan Y, Xiong Y, Sun M, Zhang Y*, Zhang X*, Geng Meng*. Structural and immunogenic characteristics of goose parvovirus virus-like particles. Virology. 2026 Feb;614:110727.

2025

1:Junyi Li, Qi Yang, Zhibo Yang, Yangnan Huyan, Yi Xiong, Miao Sun, Yueping Zhang*, Xinzheng Zhang*, Geng Meng*. Structural insights into mink enteritis virus host specificity: capsid architecture, receptor recognition, and evolutionary dynamics. One Health Advances.2025 Nov;3, 31.

2024

1：Tesfagaber W, Wang W, Wang L, Zhao R, Zhu Y, Li F, Sun E, Liu R, Bu Z, Meng Geng*, Zhao D*. A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope. Int J Biol Macromol. 2024 May;268(Pt 1):131695.

2023

1：Tan M, Xia J, Luo H, Meng Geng*, Zhu Z*. Applying the digital data and the bioinformatics tools in SARS-CoV-2 research. Comput Struct Biotechnol J. 2023 Oct 1;21:4697-4705.

2：Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng Geng, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nat Commun. 2023 May 19;14(1):2859.  

3：Fu, J., Zhang, L., Long, Y., Liu, Z., Meng Geng, Zhao, H., Su, X., Shi, S. Multiplexed CRISPR-Based Nucleic Acid Detection Using a Single Cas Protein. Analytical chemistry, 2023 Oct 26.

4：刘志斌, 孙淼, 陈延飞, 陈建, 李岭, 呼延洋楠, 薛青红*, 孟赓*. 副黏病毒糖蛋白的结构与功能研究进展[J]. 中国兽药杂志, 2023, 57 (11): 72-84.

2022

1：Meng K#, Zhang L#, Xue X, Xue Q, Sun M, Meng Geng*. Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses. J Virol. 2022 Jul 13;96(13):e0073622.

2：Zhu W, Meng K, Zhang Y, Bu Z, Zhao D*, Meng Geng*. Lateral Flow Assay for the Detection of African Swine Fever Virus Antibodies Using Gold Nanoparticle-Labeled Acid-Treated p72. Front Chem. 2022 Jan 3;9:804981.

3：Meng K#, Zhang Y#, Liu Q, Huyan Y, Zhu W, Xiang Y, Meng Geng*. Structural Design and Assessing of Recombinantly Expressed African Swine Fever Virus p72 Trimer in Saccharomyces cerevisiae. Front Microbiol. 2022 Jun 14;13:802098.

4：Qu Z, Kang H, Cui C, Meng K, Zhang X, Qu L, Zhang Y*, Meng Geng*. Purification-induced damage to calicivirus particles at near-atomic resolution. J Gen Virol. 2022 May;103(5).

2021

1：Wu H#, Xing N#, Meng K#, Fu B, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X*, Meng Geng*, Zhu Z*. Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2. Cell Host Microbe. 2021 Dec 8;29(12):1788-1801. （全球第一个报道了新冠病毒N蛋白203位点突变的表型，与诺贝奖获得者Jennifer Doudna背靠背发表）

2：Cheng J, Wu M, Zhong R, Si D, Meng Geng, Zhang R, Zhang Y. Rapid Golden Gate assembly of exons from genomic DNA for protein expression in Escherichia coli and Pichia pastoris. Biotechniques. 2021 Aug;71(2):445-450.

3：Fu J#, Zhang Y, Cai G, Meng Geng*, Shi S*. Rapid and sensitive RPA-Cas12a-fluorescence assay for point-of-care detection of African swine fever virus. PLoS One. 2021 Jul 19;16(7):e0254815.

4：Fu Y, Zhu Z, Meng Geng, Zhang R, Zhang Y. A CRISPR-Cas9 based shuffle system for endogenous histone H3 and H4 combinatorial mutagenesis. Sci Rep. 2021 Feb 8;11(1):3298.

5：Zhu, Zhenglin#*; Liu, Gexin; Meng, Kaiwen; Yang, Liuqing; Liu, Di; Meng Geng*. Rapid spread of mutant alleles in worldwide SARS-CoV-2 strains revealed by genome-wide single nucleotide polymorphism and variation analysis. Genome Biol Evol. 2021 Feb 3;13(2):evab015.（鉴定了系列流行的新冠病毒突变包括S蛋白D614G及N蛋白R203K/G204R，2020年4月16日即发表于预印版网站Research Square）

2020

1：Zhu Z*; Meng K; Meng Geng*. Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2. Scientific Reports, 2020, 10(1): 0-21617. （报道了冠状病毒间存在的跨物种重组现象，被维基百科收录）

2：Zhu, Zhenglin*; Meng, Kaiwen; Liu, Gexin; Meng Geng*. A database resource and online analysis tools for coronaviruses on a historical and global scale. Database（Oxford）, 2020. （搭建了冠状病毒基因组及蛋白组数据库）

3：Zhu ZhengLin*; Meng Geng*. ASFVdb: An integrative resource for genomic and proteomic analyses of African swine fever virus. Database（Oxford）, 2020, 1(14). （搭建了非洲猪瘟病毒基因组及蛋白组数据库）

4：Zhang, Lijie; Li, Xiaoying; Ma, Lizhen; Zhang, Bing; Meng Geng*; Xia, Chun*. A Newly Recognized Pairing Mechanism of the alpha- and beta-Chains of the Chicken Peptide-MHC Class II Complex. The Journal of Immunology, 2020, 204(6): 1630-1640. （基于鸡MHC II的结构发现了一种新的alpha和beta链配对机制）

5：Chen, Chaochao; Yu, Xuezhi; Han, Diangang; Ai, Jun; Ke, Yuebin; Wang, Zhanhui*; Meng Geng*. Non-CTAB synthesized gold nanorods-based immunochromatographic assay for dual color and on-site detection of aflatoxins and zearalenones in maize. Food Control, 2020, 118: 0-107418. （基于晶种法无CTAB制备金纳米棒的应用）

6：Zhu, Zhenglin*; Wang, Yawang; Zhou, Xichuan; Yang, Liuqing; Meng Geng*; Zhang, Ze. SWAV: a web-based visualization browser for sliding window analysis. Scientific Reports, 2020, 10(1): 0-149.  

7：Li, Zibin; Zhang, Nianzhi; Ma, Lizhen; Zhang, Lijie; Meng Geng; Xia, Chun. The Mechanism of beta 2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. ISCIENCE, 2020, 23(5): 0-UNSP 101119.

8：Zhang L.; Liu Y.; Meng Geng.; Liang R.; Zhang B.; Xia C*. Structural and Biophysical Insights into the TCRαβ Complex in Chickens. iScience, 2020, 23(12): 0-101828.

9：Ma, Lizhen; Zhang, Nianzhi; Qu, Zehui; Liang, Ruiying; Zhang, Lijie; Zhang, Bing; Meng Geng; Dijkstra, Johannes M; Li, Shen; Xia, Max Chun*. A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove. The Journal of Immunology, 2020, 204(1): 147-158.  

2019

1：Qu, Zehui; Li, Zibin; Ma, Lizhen; Wei, Xiaohui; Zhang, Lijie; Liang, Ruiying; Meng Geng; Zhang, Nianzhi*; Xia, Chun*. Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. The Journal of Immunology, 2019, 202(12): 3493-3506.

2：Guo, Jingui; Xie, Yixiao; Yu, Zhu; Meng Geng; Wu, Zhe*. Effect of Lactobacillus plantarum expressing multifunctional glycoside hydrolases on the characteristics of alfalfa silage. Applied Microbiology and Biotechnology, 2019, 103(19): 7983-7995.

3：孟凯闻; 朱文壮; 张迪; 金艺鹏; 林德贵; 孟赓*. 猫杯状病毒抗体间接ELISA检测方法的建立. 中国兽医杂志, 2019, (05): 36-39.  

4：朱文壮; 刘轶群; 孟赓*. 纳米金颗粒的晶种法制备及表征. 中国兽医杂志, 2019, 55(10): 33-35+130. （基于晶种法制备的高均一性金纳米颗粒）

2018

1：孟凯闻; 孟赓; 林德贵; 张迪; 金艺鹏*. 猫杯状病毒研究进展. 中国兽医杂志, 2018, 54(4): 60-63+1.  

2015

1：Kanekiyo M, Bu W, Joyce MG, Meng Geng, Whittle JR, Baxa U, Yamamoto T, Narpala S, Todd JP, Rao SS, McDermott AB, Koup RA, Rossmann MG, Mascola JR, Graham BS, Cohen JI, Nabel GJ. Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site. Cell. 2015 Aug 27;162(5):1090-100.

2：Liu Yue; Sheng Ju; Baggen Jim; Meng Geng; Xiao Chuan; Thibaut Hendrik J; van Kuppeveld Frank J M; Rossmann Michael G*. Sialic acid-dependent cell entry of human enterovirus D68. Nature Communications, 2015, 6: 0-8865.  

3：Liu Yue; Sheng Ju; Fokine Andrei; Meng Geng; Shin Woong Hee; Long Feng; Kuhn Richard J; Kihara Daisuke; Rossmann Michael G*. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science, 2015, 347(6217): 71-74.

2014

1：Xiao Weichun#; Meng Geng#; Zhao Yanmei; Yuan Huihui; Li Tingting; Peng Yanyan; Zhao Yong; Luo Ming; Zhao Wenming; Li Zhanguo; Zheng Xiaofeng*. Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents. Arthritis & Rheumatology, 2014, 66(5): 1141-1152.

2013

1：Wang Zhiqing; Li Long; Pennington Janice G; Sheng Ju; Yap Moh Lan; Plevka Pavel; Meng Geng; Sun Lei; Jiang Wen; Rossmann Michael G. Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody. Journal of Virology, 2013, 87(16): 8909-8915.

2：Liu Yong; Qin Kun; Meng Geng; Zhang Jinfang; Zhou Jianfang; Zhao Guangyu; Luo Ming; Zheng Xiaofeng*. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. Journal of Biological Chemistry, 2013, 288(16): 11013-11023.

3：Liu Yong; Meng Geng; Luo Ming; Zheng Xiaofeng. Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013, 69(Pt 3): 280-283.

4：Geng Meng#; Xiaojing An; Sheng Ye; Yong Liu; Wenzhuang Zhu; Rongguang Zhang; Xiaofeng Zheng*. The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system. Protein & Cell, 2013, 4(12): 897-900.

5：Meng Geng#; Zhang Xinzheng; Plevka Pavel; Yu Qian; Tijssen Peter; Rossmann Michael G*. The structure and host entry of an invertebrate parvovirus. Journal of Virology, 2013, 87(23): 12523-12530. （基于昆虫细小病毒的结构的研究阐述了细小病毒破膜及基因组释放机制）

2012

1：Battisti Anthony J#; Meng Geng#; Winkler Dennis C; McGinnes Lori W; Plevka Pavel; Steven Alasdair C; Morrison Trudy G; Rossmann Michael G*. Structure and assembly of a paramyxovirus matrix protein. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(35): 13996-14000. （第一个副黏病毒分子组装模型的报道）

2：Bai Xiaoyun#; Meng Geng#; Luo Ming; Zheng Xiaofeng*. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. Journal of Biological Chemistry, 2012, 287(26): 22387-22396.  

3：Bai Xiaoyun; Meng Geng; Zheng Xiaofeng. Cloning, purification, crystallization and preliminary X-ray diffraction analysis of mouse PACSIN 3 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012, 68(Pt 2): 159-162.  

2011

1：Zhu Wenzhuang; Meng Geng; Liu Yong; Zhang Feiyun; Zheng Xiaofeng. Protein expression, crystallization and preliminary X-ray crystallographic studies of LidA from Legionella pneumophila. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011, 67(Pt 5): 637-639.  

2：丁庆; 孟赓; 王树峰; 郑晓峰; 杨红; 龚旗煌. Ultrafast solvation dynamics of subtilisin-polyethylene glycol interaction for protein crystallization. 中国物理快报, 2011, 28(6): 0-067804.

2010

1：Li Guoming; Qu Linglong; Meng Geng; Bai Xiaoyun; Dai Kesheng; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010, 66(Pt 8): 935-937.  

2：Meng Geng#; Zhao Yanmei; Bai Xiaoyun; Liu Yong; Green Todd J; Luo Ming; Zheng Xiaofeng*. Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. Journal of Biological Chemistry, 2010, 285(51): 39898-39904.  

3：Bai Xiaoyun; Meng Geng; Li Guoming; Luo Ming; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010, 66(Pt 1): 73-75.  

2009

1：Dai Xueyu; Li Yiyu; Meng Geng; Yao Shun; Zhao Yanmei; Yu Quan; Zhang Jinfang; Luo Ming; Zheng Xiaofeng. NADPH is an allosteric regulator of HSCARG. Journal of Molecular Biology, 2009, 387(5): 1277-1285.  

2：Li Guoming; Tang Zhenting; Meng Geng; Dai Kesheng; Zhao Jindong; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65(Pt 10): 1039-1041.  

3：Meng Geng#; Bai Xiaoyun; Green Todd J; Luo Ming; Zheng Xiaofeng*. Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain-containing protein. Protein and Peptide Letters, 2009, 16(3): 336-338.  

2008

1：Meng Geng#; Zhai Ruitong; Liu Bin; Zheng Xiaofeng. Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster. Biochemistry (Mosc), 2008, 73(1): 38-43.  

2006

1：Zhai Ruitong#; Meng Geng#; Zhao Yanmei; Liu Bin; Zhang Genfa; Zheng Xiaofeng*. A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans. (FEBS Letters, 2006, 580(16): 3811-3817.

专利：

（1）孟赓（1/7），一种检测非洲猪瘟病毒抗体的胶体金免疫层析试纸卡，2021.11.03，中国，CN202111291821.1

（2）孟赓（1/2），一种不同粒径超均匀球形纳米金颗粒制备方法，2020.8.6，中国，202010502481.1

（3）孟赓（1/4），一种非洲猪瘟病毒衣壳蛋白P72及其制备方法和应用，2020.3.30, 中国, CN202010240109.8. （专利产品通过农业部非洲猪瘟检测应急评审并获得产品注册，农业部公告970号）

（4）孟赓（1/3），一种小反刍兽疫病毒抗原以及检测小反刍兽疫病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293190.X

（5）孟赓（1/3），一种猪圆环病毒 II 型抗原以及检测猪圆环病毒 II 型抗体的胶体金免疫层析试纸条，2019.12.16,中国，201911294319.9

（6）孟赓（1/4），一种牛冠状病毒嵌合抗原以及检测牛冠状病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293235.3

（7）孟赓（1/4），一种牛轮状病毒嵌合抗原以及检测牛轮状病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293233.4

（8）孟赓（1/3），一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条，2019.12.16,中国，201911300052.X