欧宝综合

欧宝综合教授，博士生导师，农业农村部兽药安全检验测试中心（北京）副主任，入选教育部新世纪优秀人才支持计划。FAO/WHO食品添加剂联合专家委员会兽药残留专家，中国食品法典专家咨询委员会委员，第二届全国兽药残留与耐药性控制专家委员会委员，全国饲料工业标准化技术委员会标准化工作组委员，北京质谱学会理事。主持国家自然科学基金、国家重点研发计划、兽药残留国家标准制修订等科研项目，在Science Bulletin、Trends in Analytical Chemistry、Environmental Science & Technology等期刊上发表SCI收录论文60余篇。

2003.9-2008.6  欧宝综合  获农学博士学位

1998.9-2003.6  欧宝综合  获农学学士学位

2019.12-至今      欧宝综合  教授

2011.12-2019.12   欧宝综合  副教授

2008.6-2011.12    欧宝综合  讲师

动物性食品和环境中化学危害物的高通量确证分析技术

基于代谢组学的细菌耐药性机制研究及控制技术

本科生课程：《兽药残留检测技术》《动物环境化学污染物分析实验》

研究生课程：《仪器分析技术》《兽药残留仪器分析》

国家重点研发计划课题：抗细菌天然产物筛选及成药性研究（2023-2027）

国家重点研发计划子课题：动物性食品中新化学危害物筛查和确证（2023-2027）

1. Liang Zhao, Jian Xu, Saiwa Liu, Jingjing Du, Xixi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Xiaowei Li, Xi Xia*. Inosine monophosphate overcomes the coexisting resistance of mcr-1 and blaNDM-1 in Escherichia coli. Journal of Advanced Research, 2026, 79, 331-341.

2. Xi Jia, Liang Zhao, Saiwa Liu, Jingjing Du, Zhinan Wang, Lirui Ge, Jian Xu, Kexin Cui, Yu Ga, Xiaowei Li, Jianzhong Shen*, Xi Xia*. Drug-resistant Escherichia coli metabolomics via pseudo-targeted SWATH/IDA-MRM: Bridging high coverage and precision. Journal of Advanced Research, 2025, doi: 10.1016/j.jare.2025.07.051.

3. Jian Xu#, Jingyu Liu#, Xiaowei Li, Liang Zhao, Jianzhong Shen*, Xi Xia*. Burden of bacterial antimicrobial resistance in China: a systematic analysis from 1990 to 2021 and projections to 2050. Journal of Advanced Research, 2025, doi: 10.1016/j.jare.2025.06.021.

4. Jingjing Du, Jian Xu, Yuanyuan Luo, Xiaowei Li, Liang Zhao, Saiwa Liu, Xi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Mengxuan Zhu, Tianrun Ji, Zelong Huang, Xi Xia*. High-throughput monitoring of 323 pharmaceuticals and personal care products (PPCPs) and pesticides in surface water for environmental risk assessment. Environmental Science & Technology, 2025, 59, 11275?11285.

5. Liang Zhao#, Jian Xu#, Xiaowei Li, Saiwa Liu, Jingjing Du, Xixi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Jianzhong Shen, Xi Xia*. Antibiotic exposure at environmental concentrations under high-fat diet: Impacts on gut microbiota and metabolism. Environment International, 2025, 202, 109679.

6. Dongyang Ye, Xiaowei Li, Liang Zhao, Saiwa Liu, Xixi Jia, Zhinan Wang, Jingjing Du, Lirui Ge, Jianzhong Shen, Xi Xia*. Oxidized glutathione reverts carbapenem resistance in blaNDM-1-carrying Escherichia coli. EMBO Molecular Medicine, 2024, 16(5): 1051-1062.

7. Dongyang Ye, Chengfei Wang, Xiaowei Li, Liang Zhao, Saiwa Liu, Jingjing Du, Xixi Jia, Zhinan Wang, Lu Tian, Jian Xu, Jing Li, Zuhao Yan, Jiangyi Ding, Jianzhong Shen, Xi Xia*. Trace antibiotics perturb the metabolism of Escherichia coli. Science Bulletin, 2022, 67, 2158-2161.

8. Dongyang Ye, Xiaowei Li, Jianzhong Shen*, Xi Xia*. Microbial metabolomics: From novel technologies to diversified applications. Trends in Analytical Chemistry, 2022, 148, 116540.

9. Jingjing Du, Xiaowei Li, Lu Tian, Jing Li, Chengfei Wang, Dongyang Ye, Liang Zhao, Saiwa Liu, Jian Xu, Xi Xia*. Determination of macrolides in animal tissues and egg by multi-walled carbon nanotube-based dispersive solid-phase extraction and ultra-high performance liquid chromatography–tandem mass spectrometry. Food Chemistry, 2021, 365, 130502.

10. Chengfei Wang#, Dongyang Ye#, Xiaowei Li, Yanbo Jia, Liang Zhao, Saiwa Liu, Jian Xu, Jingjing Du, Lu Tian, Jing Li, Jianzhong Shen, Xi Xia*. Occurrence of pharmaceuticals and personal care products in bottled water and assessment of the associated risks. Environment International, 2021, 155, 106651.

11. Chengfei Wang, Xiaowei Li, Fugen Yu, Yingyu Wang, Dongyang Ye, Xue Hu, Lan Zhou, Jingjing Du, Xi Xia*. Multi-class analysis of veterinary drugs in eggs using dispersive-solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Food Chemistry, 2021, 334, 127598.

12. Yingyu Wang, Xiaowei Li, Yulin Fu, Yiqiang Chen, Yang Wang, Dongyang Ye, Chengfei Wang, Xue Hu, Lan Zhou, Jingjing Du, Jianzhong Shen*, Xi Xia*. Association of florfenicol residues with the abundance of oxazolidinone resistance genes in livestock manures. Journal of Hazardous Materials, 2020, 399, 123059.